The Anal Pap:
A guide for primary care providers
CONTENTS:
Introduction
Histopathology
How to perform an anal pap
Treatment
Epidemiology
Cost-effectiveness
Who and how often to screen
Anal pap at a glance
Links
Anal pap: does it qualify to be a screening test?
Bibliography
Basic Science of HPV
THE CRITERIA:
Disease with substantial burden of suffering
Sensitive and specific test for disease
Simplicity of test
Cost
Safety of test
Acceptability to clinician and patient of test
Click for PROS
Click for CONs
Labeling of patient with positive result
Effectiveness of therapy
ANAL PAP AS SECONDARY PREVENTION:
An exercise in evidence based medicine

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The anal pap is a procedure that is being used by many health care providers as a screening tool for high-grade anal dysplasia, a lesion thought to be a precursor to anal cancer.   The incidence of this tumor appears to be higher in men who have sex with men (MSMs) and HIV+ patients when compared to the rest of the general population.  The goal of the following document is to test the hypothesis that the anal pap should be implemented as a secondary preventative strategy.
     There is no clear test with a binary result of yes or no to help clinicians discern whether an intervention should be implemented as a screening test or not.  Approaching the anal pap in an evidence-based approach, however, may help clinicians make a decision about inclusion or exclusion of this intervention in their daily practice.
     What then makes a good screening test?  Several elements come together to help clinicians decide which interventions merit inclusion into their battery of screening interventions.  Let's apply these to the anal pap as a means of evaluating this test for inclusion in the practice’s screening guidelines.

Hypothesis: The anal pap is an appropriate screening tool for HSIL as a precursor to anal cancer in at risk groups.

Test: Does the anal pap meet criteria for inclusion in  routine screening?
N/A
YOU BE THE JUDGE. . .

CONCLUSION

The Anal Pap:
A guide for primary care providers
Demetre Daskalakis, MD

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